Description

Cabergoline(active ingredient) – suppresses the secretion of prolactin, in addition, enhances libido and erection, significantly reduces the recovery time between sexual intercourse, and also lowers blood pressure. Cabergoline belongs to the derivatives of ergot alkaloids, according to the mechanism of action – an agonist of dopamine (D2) receptors. It is a more modern and safe analogue of bromocriptine.

The drug allows you to almost completely eliminate the main side effects of steroids such as Deca (Deca-dik) and Trenbolone. One of the effects caused by a decrease in prolactin concentration is a decrease in fluid retention in tissues, which leads to an increase in leaner muscle mass.

Mechanism of action

The main mechanism of action of cabergoline is the activation of D2 receptors, which are located on lactotrophic pituitary cells. Excitation of dopamine receptors in this area leads to a decrease in the secretory function of prolactin-producing cells.

In addition, interaction with other receptors was established: D3, D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B. Antagonism with α2B receptors additionally explains the positive effect on erectile function (there is an expansion of the cavernous bodies).

APPLICATIONS IN BODYBUILDING

Experience with Iron Factor and Do4a.com has shown that the optimal scheme for using cabergoline to lower prolactin is as follows:

• During the course of progestin anabolic steroids (nandrolone, trenbolone): 0.25 mg (whole or 1/2 tab.) every 7-21 days, starting from the third or fourth week of the course, when the ACC concentration approaches its maximum.The optimal dose and frequency of administration is selected under the control of analyzes of the level of prolactin, since the effect of the drug is different and depends on the individual characteristics of the organism.
• With an increase in the level of prolactin above the permissible frequency of administration increases: 0.25 mg, every 4 days. It is desirable to perform a control analysis of prolactin after two doses, followed by a correction of the scheme.

The drug is taken both with food and on an empty stomach.

SIDE EFFECTS

A study in 200 patients with parkinsonism using high doses of cabergoline (0.5 mg every day) reports the following side effects:

• Digestive system (most common): nausea, constipation, dry mouth, dyspepsia
• Nervous system: insomnia, dizziness, depression, distortion of consciousness
• Cardiovascular system: drop in blood pressure, peripheral edema, arrhythmia, valve damage, pericarditis
• From the immune system: infrequently – hypersensitivity reaction, skin rash.
• From the side of the hematopoietic system: infrequently – erythromelalgia.
• From the respiratory system: often – shortness of breath, infrequently – pleural effusion, pulmonary fibrosis, epistaxis.

When using low dosages, side effects are quite rare or completely absent. The forums most often report depressed mood and loss of appetite.

It is not recommended to take more than one tablet per week (with the exception of a very high level of prolactin).